C. W. Post, LIU:
•Recieved grants from Research Committee, C. W. Post (2001, 2002, and 2003)
•Collaborations
•Established active research lab
•Mentoring graduate students towards Mater's thesis: HSMB 707/708 .

CUNY Medical School, New York:
•IgD-R cross-linking studies
•Characterization of murine IgD receptor (s)
•Generation of monoclonal antibodies to the IgD-R
•During this time collaborative studies were performed
with Dr. GJ Thorbecke, Department of Pathology,
NYU Medical Center.
•Supervisor of graduate and undergraduate research projects

North Shore University Hospital, Manhasset, NY:
• CD4 cross-linking studies, related Intracellular signaling events.
• Generation of mutant HIV envelope proteins,
transfections, & functional studies on these cells
• Chemokine pattern in relation to disease state
in HIV-infected children
• Effect of treatment with protease inhibitors on T cell function
in HIV infected adult population

Present Research Activities:
T cell activation including signal transduction, cytokines and apoptosis; rescue from apoptosis; (human and murine systems).

Publications:

1 Tamma, SL. and Richard F. Coico. IgD-Receptor (IgD-R) Cross-Linking Partially Protects Murine T cells from Dexamethasone-induced Apoptosis (J. Leuk. Biol.; 73: 764-770, 2003)

2 Tamma, SL, Kalyanaraman VS, Pahwa S, Dominguez P and Modesto RR. The Lectin Jacalin-Induces Tyrosine Phosphorylation of PLC-g1 and Activation of p21 RAS in CD4+ T cells (In Press, J. l of Leuk. Bioy, 73: 682-688, 2003)

3 Tamma, SL, Yan Wu, Toporovsky I, Lima V, and Coico R. IgD-R-cross-linking-induced signal transduction in Murine T cells. FASEB J A317: 241.27, 2002.

4 Tamma, SL, and Coico R. IgD-Receptor (IgD-R) Cross-Linking Partially Protects Murine T cells from Dexamethasone-induced Apoptosis FASEB J A317: 241.28, 2002.

5 Tamma, SL., Yan Wu, Igor Toporovsky, Viera Lima, and Richard F. Coico. “IgD-Receptor – Mediated Signal Transduction in T cells.” Cellular Immunology 207 (2001): 110-117.

6 Yan Wu, Tamma SL., Lima V., and Coico R. “Facilitated Antigen presentation by B cells expressing IgD when responding T cells express IgD - receptors.” Cellular Immunology 192 (1999): 194 - 202,.

7 Chavan, S., Tamma SL., Kaplan M., Gersten M., and Pahwa S. “Reduction in T cell apoptosis in patients with HIV disease following antiretroviral therapy.” Clinical Immunology 93 (1999): 24-33.

8 Than S, Tumaliuan JA., Tamma SL., Tetali S., Bakshi S., and Pahwa S.
“ Chemokine pattern in relation to disease state in Human-Immunodeficiency Virus infected children.” AIDS Research and Human Retroviruses 15 (1999): 1279-85.

9 Chirmule N., Avots,A., Tamma SL., Pahwa S., and Edgar Sefling. “ CD4-mediated signals induce T cell dysfunction in vivo.” Journal of Immunology 163 (1999): 644-649.

10 McCloskey, TW., Chavan S., Tamma SL., and Pahwa S. “ Comparison of seven quantitative assays to assess lymphocyte cell death during HIV infection: Measurement of induced apoptosis in anti-Fas-treated Jurkat cells and spontaneous apoptosis in peripheral blood mononuclear cells from children
infected with HIV.” AIDS Research and Human Retroviruses 14 (1998):1413-1422.

11 Swenson, CD., Patel T., Parek RB., Tamma SL., Coico R., Thorbecke GJ, and Amin AR. “Human T cell IgD receptors react with O-glycans on both human IgD and IgA1.” European Journal of Immunology 28 (1998): 2366-2372.

12 Tamma SL. Chirmule N. Yagura H. Oyaizu N. Kalyanaraman VS., and Pahwa S. “ CD4 crosslinking (CD4XL) with HIV-gp160 induces ras activation and TNF-? secretion in CD4+ T cells. Blood 90 (1997): 1588-1593.

13 Tamma SL., Chirmule N., Oyaizu N., McCloskey T., Kalyanaraman VS., and Pahwa S. “Signals transduced through the CD4 molecule interferes with TCR/CD3-mediated ras activation leading to T cell anergy.” Clinical Immunology and Immunopathology 85-2 (1997): 195-201.

14 Tamma SL., Oyaizu N., McCloskey T., Kalyanaraman VS., and Pahwa S. “HIV-1 gp120 blocks Jacalin induced proliferative response in CD4+ T cells: Jacalin as useful surrogate marker for qualitative and quantitative deficiency of CD4+ T cells in HIV-1 infection.” Clinical Immunology and Immunopathology 80 (1996): 290 – 297.

15 Tamma SL., Sundaram S., Meir Lev and Coico RF. “Effects of sphingolipid synthesis inhibitors on selective down-modulation of CD4 expression by helper T lymphocytes.” Biophys. Biochem. Res. Commun. 220 (1996): 916 - 921.

16 Wei CF, Tamma SL., Coico RF., Swenson CD., Amin AR., and Thorbecke GJ. “IgD- Receptor+ human T lymphocytes II. Defective upregulation of IgD receptors on T cells from aged humans: total absence of any IgD receptor in a large percentage of healthy aged individuals.” Aging: Immunol and Infect Dis.
1 (1993): 169-185.

17 Tamma SL., Coico RF. “IgD receptor positive human T lymphocytes II: Identification and partial characterization of human IgD binding factors.” Journal of Immunology 148 (1992): 2050- 57.

18 Amin AR., Tamma SL., Swenson CD, Keida CC., Oppenheim JD, Finkelman FD, Coico RF. “Murine IgD-induced immunoaugmenting properties reside in the C?3 regions of IgD.” International Immunology 5 (1992): 607-614.

19 Tamma SL., Amin AR., Finkelman FD., Wuchen Y., Thorbecke GJ., and Coico RF. “ IgD receptors on murine T helper cells binds to Fd and Fc regions of immunoglobulin D.” Proc. Natl. Acad. Sci. 88 (1991): 9233-37.

20 Tamma SL., Amin AR., Oppenheim JD., Finkelman FD.,Keida C., Coico RF., and Thorbecke GJ. “The specificity of the murine IgD receptor on T cells for N- linked glycans on IgD molecules.” Proc. Natl. Acad. Sci. 88 (1991): 9238-42.

21 Coico RF., Tamma SL., Bessler M., Wei CF., and Thorbecke GJ. “IgD receptor positive human T lymphocytes I: modulation of receptor expression by oligomeric IgD and lymphokines.” J Immunology 45 (1990): 3556: 61.

22 Cassells AC and Tamma SL. “Survival and division in protoplasts from tobacco
(Nicotiana tabacum) depends on the physiological state of the individual donor
plant.” Physiologia Plantarum 69 (1987): 317-322. Copenhagen.

23 Cassells AC and Tamma SL. “ Ethylene and ethane release during tobacco protoplast isolation and protoplast survival potential in vitro.” Physiologia Plantarum 66 (1986): 303-308. Copenhagen

Selected Abstracts/Presentations:

1 Tamma, SL, Kalyanaraman VS, Pahwa S, Dominguez P and Modesto RR The Lectin Jacalin-Induces Tyrosine Phosphorylation Of PLC-&[gamma]1 And Activation Of p21 RAS In CD4+ T Cells. FASEB Meeting, 2003 April, San Diego.

2 Tamma, SL. HIV-1 Envelope Protein gp120 Inhibits Jacalin-Induced Signal Transduction and Activation of CD4+ T cells. Submitted for publication in a booklet of C.W.Post Faculty Research Projects for 2001-02.

3 Tamma, SL. Gene Therapy. Presented at Science EXPO 2002, C.W.Post Campus (page 14, # 116)

4 Tamma, SL. IgD-R cross-linking-induced signal transduction and apoptosis in murine 7C5 T hybridoma cell and splenic T cells from BALB/c mice. Submitted for publication in a booklet of C.W.Post Faculty Research Projects for 2000-01(page 82 in the booklet)

5 Yan Wu, Tamma SL, Lima V and Coico R. Facilitated antigen presentation by B cells expressing IgD when responding T cells express upregulated IgD receptors. FASEB J, # 480.28, 1999.

6 Felix Assemenia, Roberto Carrillo, Tamma SL and Richard Coico. Role of IgD-Receptors in apoptosis. National Minority Symposium, Nov 21-24, New York, F61, p118, 1998.

7 Tamma SL, Chavan S., Kaplan M., Gersten M., and Pahwa S. Partial restoration of immune function in HIV-infected patients treated with highly active antiretroviral therapy Key Stone Meeting, Colorado, 1998.

8 Tumaliuan JA, Than S, Tamma SL, Tetali S, Bakshi S and Pahwa S. Constitutive mRNA expression of MIP-1? and MIP-1? in relation to immune status in HIV- infected children . AAAAI/AAI/CIS Joint Meeting, Abstract # 1064. 1997.

9 Tamma SL, Chirmule N., Oyaizu N., McCloskey T., Kalyanaraman VS., and Pahwa S. CD4 crosslinking with HIV gp160 induces ras activation and TNF-? secretion in CD4+ T cells. Third Conference on Retroviruses and Opportunistic Infections. Washington DC. 1996.

10 Tamma SL, McCloskey T, Oyaizu N, Chirmule N, Kalyanaraman VS and Pahwa S. “HIV-1 hp120 blocks Jacalin induced proliferative response in CD4+ T cells: Jacalin and gp120 compete to the distinct region on CD4+ molecule other than OKT4A/Leu3a”. FASEB J 9: 1174, 1995. (Presented in Minisymposium).

11 Tamma SL and Coico RF. Identification and partial characterization of human IgD-binding factor. FASEB Anaheim, CA 1992.

12 RF Coico and Tamma SL. Characterization of membrane and soluble human IgD-receptors. 8th International Congress of Immunology, Budapest, Hungary, 1992.

13 Tamma SL and Coico RF. Release of human IgD-Binding factor by IgD-R+ T cells. FASEB, #7823,Atlanta, 1991.

14 Tamma SL, Amin AR, Finkelman FD, Chen YW, Oppenheim J, Thorbecke GJ and Coico RF. Lectin like properties of IgD receptors expressed by murine T cells. ASBMB/AAI meeting in New Orleans, 1990.

15 Coico RF, Tamma SL, Wei CF, Wu WC, Bessler M, and Thorbecke GJ. IgD Receptors expressed by human CD4+ T cells ASBMB/AAI meeting in NewOrleans, 1990.

16 Amin AR, Coico RF, Tamma SL, Finkelman FD, Oppenheim JD, Thorbecke GJ. Characterization of receptors for IgD in murine T cells. 10th GCC, INSERM U-25 Paris, 1990.

17 Amin AR, Coico RF, Tamma SL, Finkelman FD, Oppenheim JD and Thorbecke GJ. Characterization of receptors for IgD on T cells. European Federation of Immunological Societies ,10th Meeting, Edinburgh,1990.

18 Coico RF, Amin AR, Tamma SL, Finkelman FD, Thorbecke GJ. Characterization and specificity of IgD receptors on T cells. 7th International Congress of Immunology, Berlin, 19-6, 1989.

19 Tamma SL, Amin AR, Finkelman FD, Thorbecke GJ, and Coico RF. IgD receptors Expressed by T cells appear to be specific for the Hinge region of IgD. FASEB New Orleans, 1989.

20 Coico RF, Swenson CD, Tamma SL, Siskind GW, Thorbecke GJ. Deficiency of IgD receptor+ T cells in aged mice and humans. Biomedical Advances in Aging VIIIth. International Washington Spring Symposium. 1988.